MAKK1/3 (fosfo-Tyr205/222) Antilichaam

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

5594;5595

P28482; P27361

NP_002736.3

Human, Mouse, Rat

MAPK1/3 (phospho Tyr205/222) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 205/222 (K-G-Y (p) -T-K) derived from Human MAPK1/3 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

44 kDa

IgG

The antibody detects endogenous levels of MAPK1/3 only when phosphorylated at tyrosine 205/222.

Western Blot: 1:500~1:1000

MAPK1, MAPK3

Mitogen-activated protein kinase 1, mitogen-activated protein kinase 3

Homo sapiens

Owaki H., Biochem. Biophys. Res. Commun. 182:1416-1422 (1992) .

Dunham I., Nature 402:489-495 (1999) .

ERK, ERT1, MAPK 1, MAPK2, ERK2

WB

66932916

Liquid