MAO-B-IN-47

MAO-B-IN-47 is a selective monoamine oxidase B (MAO-B) inhibitor with a Ki of 875 nM. MAO-B-IN-47 shows an IC50 >100 μM for SH-SY5Y cells. MAO-B-IN-47 shows neuroprotective effect in 6-OHDA-treated SH-SY5Y cells. MAO-B-IN-47 can be used for the research of neurological disease, such as Parkinson’s disease (PD) [1].

67082-01-3

12352005

H302-H315-H319-H335

Monoamine Oxidase

Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

O=C(C1=CC(C(F)(F)F)=CC=C1)CCC2=CC=CC=C2

C16H13F3O

278.27

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Facchetti G, et al. Design, synthesis, and biological evaluation of chalcone derivatives as selective Monoamine Oxidase-B inhibitors with potential neuroprotective effects. Eur J Med Chem. 2025 Nov 15;298:117990.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W628136/

Reference compound1

No Development Reported

MAO-B