MAP1 Antilichaam

MAP1 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

64112

Q96BY2

NP_071434

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis, Neuroscience, Signal Transduction

MAP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

MAP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MAP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MOAP1

Modulator of apoptosis 1

Homo sapiens

Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.

Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.

Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.

Tan KO, Tan KML, Chan S-L, et al. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J. Biol. Chem. 2001; 276:2802-7.

MAP1 Antibody: MAP-1, PNMA4, Modulator of apoptosis 1, Paraneoplastic antigen Ma4, MAP-1

ELISA, WB

19923584

Liquid