MAP1LC3B Antilichaam

Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and plasticity (1) . MAP1LC3B belongs to the MAP1 LC3 family and it includes 3 different light chains, LC1, LC2 and LC3 (2) . MAP1LC3B is involved in formation of autophagosomal vacuoles (autophagosomes) (3) . It is most abundant in heart, brain, skeletal muscle and testis. MAP1LC3B is essential for autophagy and associated to the autophagosome membranes after processing (4) .

81631

Q9GZQ8

NP_073729

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

MAP1LC3B antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

MAP1LC3B antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MAP1LC3B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MAP1LC3B antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3B are known to exist. MAP1LC3B antibody is predicted to not cross-react with MAP1LC3A or MAP1LC3C

MAP1LC3B

Cat. No. 10-301 - Human Brain Tissue Slide

Microtubule-associated protein 1 light chain 3 beta

Homo sapiens

Mandelkow E and Mandelkow EM. Microtubules and microtubule-associated proteins. Curr. Opin. Cell Biol. 1995; 7:72-81.

Fink JK, Jones SM, Esposito C, et al. Human microtubule-associated protein 1A (MAP1A) gene: genomic organization, cDNA sequence, and developmental and tissue-specific expression. Genomics 1996; 35:577-85.

Colecchia D, Strambi A, Sanzone S, et al. MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy 2012; 8:1724-40.

Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homolog of yeast Apg8p, is localized in autophagosome membrane after processing. EMBO J. 2000; 19:5720-8.

MAP1LC3B Antibody: LC3B, ATG8F, MAP1LC3B-a, MAP1A/1BLC3, MAP1ALC3, Autophagy-related protein LC3 B

ELISA, WB, IHC-P, IF

12383056

Liquid