MAP2K2 Antilichaam - N-terminalgebied: FITC (ARP48941_P050-FITC)

Mitogen-activated protein kinase kinase 2

CFC4, MEK2, MKK2, MAPKK2, PRKMK2

5605

P36507

NP_109587

Human, Mouse, Rat, Cow, Dog, Guinea Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human MAP2K2

MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CCNDBP1; RAF1; SUMO2; UBC; EGFR; IQGAP1; NFE2L2; YWHAB; MAPK1; PEX14; BRAF; ARAF; FAM65B; ZNF207; LIG4; MAPK8; WDR83; Ksr1; COPS5; MAP2K1; MEPCE; GRIN1; CNKSR1; LAMTOR3; GRIN2D; RGS12; CASP9; MAPK3; MAP2K2; DUSP3; Flna

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB, IHC

Affinity Purified

There is BioGPS gene expression data showing that MAP2K2 is expressed in HepG2

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

44kDa

Adjei, A.A., (2008) J. Clin. Oncol. 26 (13), 2139-2146

Wet Ice

400

MAP2K2

MAP2K2

Rabbit

Dual specificity mitogen-activated protein kinase kinase 2

NM_030662

LARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQK