MAP2K3 (fosfo Thr222) Antilichaam

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells.

5606

P46734

NP_659731.1

Human, Mouse, Rat

MAP2K3 (phospho Thr222) antibody was raised against a peptide sequence around phosphorylation site of threonine 222 (A-K-T (p) -M-D) derived from Human MAP2K3 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

39 kDa

IgG

The antibody detects endogenous levels of MAP2K3 only when phosphorylated at threonine 222.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

MAP2K3

Mitogen-activated protein kinase kinase 3

Homo sapiens

Derijard B., Science 267:682-685 (1995) .

Moriguchi T., J. Biol. Chem. 271:26981-26988 (1996) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

MAP2K3, MAPKK 3, MEK3, MP2K3, PRKMK3

WB, IHC

24638466

Liquid