MAP2K7 (fosfo Ser271) Antilichaam

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

5609

O14733

NP_660186.1

Human, Mouse, Rat

MAP2K7 (phospho Ser271) antibody was raised against a peptide sequence around phosphorylation site of Serine271 (V-D-S (p) -K-A) derived from Human MAP2K7.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

60 kDa

IgG

The antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

MAP2K7

Mitogen-activated protein kinase kinase 7

Homo sapiens

Wu Z., Mol. Cell. Biol. 17:7407-7416 (1997) .

Lu X., J. Biol. Chem. 272:24751-24754 (1997) .

Foltz I.N., J. Biol. Chem. 273:9344-9351 (1998) .

PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7

WB, IHC

21735544

Liquid