MAP3K7IP1 Antilichaam - N-terminalgebied HRP (ARP53182_P050-HRP)

TGF-beta activated kinase 1/MAP3K7 binding protein 1

3'-Tab1, MAP3K7IP1

10454

Q8IZW2

NP_705717

Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1

The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

MAGED1; BAG2; MAP3K7; TIRAP; MDM2; SLMAP; NPM1; BIRC3; TRIP6; PPP2R1A; PPP2CB; GRB2; FN1; CDK5RAP3; TAB2; CORO1A; WTAP; MAPK8IP1; UBC; MAPK14; BST2; MAPK12; HSP90AA1; NOTCH1; IKBKB; GRK5; EGFR; STE11; BIRC7; NAIP; XIAP; OGT; TAB3; NR2C2; ARRB2; ARAP1; ACA

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

50kDa

Neil, J.R. (2008) Cancer Res. 68 (5), 1462-1470

Wet Ice

462

TAB1

TAB1

Rabbit

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

NM_153497

MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPE