MAP3K8 Antilichaam

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

1326

P41279

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K8 (NP_005195.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Immunology, Signal Transduction

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 58kDa

IgG

WB: 1:500 - 1:2000

MAP3K8

Mitogen-activated protein kinase kinase kinase 8

Homo sapiens

MAP3K8, COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT

WB

Liquid