MAP3K8 Antilichaam - C-terminalgebied: HRP (ARP30649_T100-HRP)

Mitogen-activated protein kinase kinase kinase 8

COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT

1326

P41279

NP_005195

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K8

MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) . This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

RELA; MAP2K1; RIPK1; NFKB1; ACY3; STIP1; HSP90AA1; TAB2; TRAF6; TRAF2; CD40; TNIP2; Nedd4; MAP3K14; MAP2K4; BMPR2; CHUK; REL; AKT1; NFKB2; KSR2

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 77%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Jia, Y., et al., (2005) Arch. Biochem. Biophys. 441 (1), 64-74

Wet Ice

467

MAP3K8

MAP3K8

Rabbit

Mitogen-activated protein kinase kinase kinase 8

NM_005204

PRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLY