MAP3K8 (fosfo Ser400) Antilichaam

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) .

1326

P41279

NP_001231063.1

Human, Mouse, Rat

MAP3K8 (phospho Ser400) antibody was raised against a peptide sequence around phosphorylation site of Serine 400 (C-Q-S (p) -L-D) derived from HumanMAP3K8.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

52 kDa

IgG

The antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400.

MAP3K8

Mitogen-activated protein kinase kinase kinase 8

Homo sapiens

Miyoshi J., Mol. Cell. Biol. 11:4088-4096 (1991) .

Aoki M., J. Biol. Chem. 268:22723-22732 (1993) .

Chan A.M., Oncogene 8:1329-1333 (1993) .

C-COT; , M3K8, MAP3K8, TPL2

IHC

22035598

Liquid