MAP3K8 Mouse Monoclonal Antibody [Kloon ID: LBI2E10]

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Carrier-free (BSA/glycerol-free) MAP3K8 mouse monoclonal antibody, clone LBI2E10

AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Homo sapiens mitogen-activated protein kinase kinase kinase 8 (MAP3K8), transcript variant 1, mRNA.

1326

P41279

Unconjugated

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Protein Kinase

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

MAP3K8

https://www.ncbi.nlm.nih.gov/gene/?term=1326

https://www.uniprot.org/uniprot/P41279