MAP4K3 Antilichaam

MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1) . This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) .

8491

Q8IVH8

Q8IVH8

Human

This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3.

Unconjugated

Primary Antibodies

Cancer, Obesity, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

101 kDa

Rabbit Ig

MAP4K3

Mitogen-activated protein kinase kinase kinase kinase 3

Homo sapiens

Yan, L., et al. Mol. Cell 37 (5) :633-642 (2010)

Ichikawa, S., et al. J. Bone Miner. Res. (2010) In press :

Lam, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (29) :11978-11983 (2009)

Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1

WB, IHC-P, Flow

29427817

Liquid