MAPK9 Antilichaam, KO gevalideerd

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

5601

P45984

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human MAPK9 (NP_002743.3) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Apoptosis, Cancer, Cell Cycle, Immunology, Innate Immunity, Neuroscience, Signal Transduction

Affinity purification

MCF-7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 54kDa

IgG

MAPK9

DU145

THP-1

Mouse liver

Mitogen-activated protein kinase 9

Homo sapiens

MAPK9, stress-activated protein kinase JNK2, SAPK, PRKM9, p54aSAPK, p54a, OTTHUMP00000161543, OTTHUMP00000161542, mitogen-activated protein kinase 9, MAPK 9, MAP kinase 9, Jun kinase, JNK-55, JNK2BETA, JNK2B, JNK2ALPHA, JNK2A, JNK2, c-Jun N-terminal kinase 2, c-Jun kinase 2, SAPK1A

WB, IHC, IF

Liquid