MAPKBP1 Antilichaam

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

23005

O60336

Human, Mouse

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1) .

Unconjugated

Primary Antibodies

Signal Transduction

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 164kDa

IgG

WB: 1:500 - 1:2000

MAPKBP1

Mouse liver

Mouse lung

Mitogen-activated protein kinase binding protein 1

Homo sapiens

JNKBP-1, JNKBP1, NPHP2mitogen-activated protein kinase-binding protein 1, JNK-binding protein 1

WB

Liquid