Martentoxine

Martentoxin, a 4,046 Da polypeptide toxin, is a large-conductance Ca2+-activated K+ (BKCa) channel inhibitor. Martentoxin attenuates NO release, inhibits iNOS activation and upregulates eNOS mRNA expression in HUVECs induced by TNF-α. Martentoxin can be used for vascular diseases research[1].

12352209

NO Synthase; Potassium Channel

Immunology/Inflammation; Membrane Transporter/Ion Channel

Inflammation/Immunology; Cardiovascular Disease

O=C(NCC(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H]1CCC(N)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCNC(N)=N)=O)NC1=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC7=CC=C(C=C7)O)C(O)=O)=O)NC4=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(NCC(N[C@@H](CCC(N)=O)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC8=CC=CC=C8)N

C171H262N50O53S6

4058.60

[1]Wang J, et al. Martentoxin, a large-conductance Ca (2+) -activated K (+) channel inhibitor, attenuated TNF-α-induced nitric oxide release by human umbilical vein endothelial cells. J Biomed Res. 2013 Sep;27 (5) :386-93.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P3168/

Peptides

No Development Reported

ENOS; iNOS