Masticadiënonzuur

Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease[1].

514-49-8

12352211

Keap1-Nrf2; NF-κB; p38 MAPK

MAPK/ERK Pathway; NF-κB

COVID-19-immunoregulation

Inflammation/Immunology

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C30H46O3

454.68

[1]Cui H, et al. Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota. Phytomedicine. 2023 Jan;108:154518.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N8563/

Natural Products

No Development Reported