MATN3 Antilichaam

MATN3 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs) . MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.

4148

O15232

AAI39908

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

MATN3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1471 - Rat Thymus Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (85%)

MATN3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MATN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MATN3

Cat. No. 17-201 - 3T3/BALB Cell Slide

Matrilin 3

Homo sapiens

Pei M, Luo J, and Chen Q. Enhancing and maintaining matrilins. Osteoarthritis Cartilage2008; 16:1110-7.

Frank S, Schulthess T, Landwehr R, et al. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. J. Biol. Chem.2002; 277:19071-9.

Chen Q, Johnson DM, Haudenschild DR, et al. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev. Biol.1995; 172:293-306.

Stokes DG, Liu G, Coimbra IB, et al. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum2002; 46:404-19.

MATN3 Antibody: HOA, OS2, EDM5, DIPOA, OADIP, Matrilin-3

ELISA, WB, ICC, IF

146218451

Liquid