MBA-m1
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MBA-m1 is a MLKL inhibitor. MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells. MBA-m1 ameliorates disease in MLKL-induced dermatitis and abdominal aortic aneurysm mouse model[1].
305866-70-0
12352005
H302, H315, H319, H335
Mixed Lineage Kinase
MAPK/ERK Pathway
COVID-19-immunoregulation
Cancer; Inflammation/Immunology
95.71
ClC1=CC(NC2=CC(C)=NC3=C2C=C(OC)C=C3)=CC=C1OC4=CC5=C(C=CC=C5)C=C4
C27H21ClN2O2
440.92
H302, H315, H319, H335
[1]Ros U, et al. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 17;85 (8) :1589-1605.e12.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-24504/MBA-m1-SDS-MedChemExpress.pdf
Reference compound2
No Development Reported
Beschrijving
MBA-m1 is a MLKL inhibitor. MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells. MBA-m1 ameliorates disease in MLKL-induced dermatitis and abdominal aortic ane
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