MBP (myeline basiseiwit) Antilichaam

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

4155

P02686

NP_001020252.1

Human, Mouse, Rat

MBP (myelin basic protein) antibody was raised against a peptide sequence around aa.291~295 (G-G-R-D-S) derived from Human MBP.

Unconjugated

Primary Antibodies

Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

14~33 kDa

This antibody detects endogenous level of total MBP (myelin basic protein) protein.

Western Blot: 1:500~1:1000

MBP

Myelin basic protein

Homo sapiens

Pribyl T. M., Campagnoni C. W., Kampf K., Kashima T., Handley V. W., McMahon J., Campagnoni A. T. Proc. Natl. Acad. Sci. U. S. A. 90:10695-10699 (1993) Nye S. H., Pelfrey C. M., Burkwit J. J., Voskuhl R. R., Lenardo M. J., Mueller J. P. Mol. Immunol. 32:1131-1141 (1995)

MGC99675

WB

68509930

Liquid