MC-Val-Ala-NHS-ester
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.
1895916-22-9
12352203
ADC Linker
Antibody-drug Conjugate/ADC Related
Cancer-programmed cell death
Cancer
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(ON2C(CCC2=O)=O)=O)=O)=O
C22H30N4O8
478.50
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W591479/
ADC Related
No Development Reported
Beschrijving
MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group
Specificaties
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