MC1R Antilichaam

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH) . The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

4157

Q01726

Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human MC1R (NP_002377.4) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

Mouse testis

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 37kDa

IgG

WB: 1:500 - 1:2000

MC1R

Rat skin

Melanocortin 1 receptor

Homo sapiens

CMM5, MSH-R, SHEP2, melanocyte-stimulating hormone receptor, MC1-R, alpha melanocyte stimulating hormone receptor, melanotropin receptor

WB

Liquid