MCAM Antilichaam [C264]

Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm’s kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes.

448832

Chicken, Turkey

Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos

[C264]

Unconjugated

Primary Antibodies

Cancer, Immunology, Signal Transduction

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

MCAM

MCAM Antibody [C264] for use in flow cytometry, immunocytochemistry, and immunoprecipitation assays.

MCAM

Melanoma cell adhesion molecule

Gallus gallus

CD146, HEMCAM, melanoma cell adhesion molecule

IHC-Fr, Flow, IP

Liquid