MCC-950
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model) 3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
Unconjugated
White solid
-20°C
Beschrijving
MCC-950 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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