MCG10 Antilichaam

MCG10 Antibody: MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.

57060

P57723

EAW65166

Human

Unconjugated

Primary Antibodies

Apoptosis

MCG10 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Mouse: (100%), Bovine: (100%)

MCG10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MCG10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PCBP4

Cat. No. 17-001 - HeLa Cell Slide

Poly (rC) binding protein 4

Homo sapiens

Makeyev AV and Liebhaber SA. The poly (C) -binding proteins: a multiplicity of functions and a search for mechanisms. RNA2002; 8:265-78.

Zhu J and Chen X. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G2-M. Mol. Cell Biol.2000; 20:5602-5618.

Pio R, Zudaire I, Pino I, et al. a-CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant aCP-4a, is underexpressed in lung cancer. Cancer Res.2004; 64:4171-9.

MCG10 Antibody: CBP, LIP4, MCG10Alpha-CP4

ELISA, WB, ICC, IF

119585570

Liquid