MCL1 Antilichaam [86D4B1]

Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

4170

Q07820

NP_001184249.1

Human

Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15.

8C6D4B1

Unconjugated

Primary Antibodies

Apoptosis

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

MCL-1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

MCL1

Myeloid cell leukemia sequence 1 (BCL2-related)

Homo sapiens

Ota, N. et al. J. Hum. Genet. 2000. 46: 254-269.

Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251.

TM, EAT, MCL1L, MCL1S, Mcl-1, BCL2L3, MCL1-ES, bcl2-L-3, mcl1/EAT

ELISA, WB, IHC

309747067