Mcl1-IN-15
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1].
518303-27-0
12352005
H302-H315-H319-H335
Apoptosis; Bcl-2 Family
Apoptosis
Cancer
O=C(O)CSC1=CC(NS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)=C3C=CC=CC3=C1O
C22H23NO5S2
445.55
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
[1]Abulwerdi FA, et al., 3-Substituted-N- (4-hydroxynaphthalen-1-yl) arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57 (10) :4111-33.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W286906/
Reference compound1
No Development Reported
Mcl-1
Beschrijving
Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activate
Specificaties
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