MCM2 Antilichaam

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

4171

P49736

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human MCM2 (NP_004517.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Stem Cell

Affinity purification

SW480

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 130kDa

IgG

MCM2

SH-SY5Y

Raji

A-549

HeLa

HL-60

Minichromosome maintenance complex component 2

Homo sapiens

MCM2, BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN

WB, IHC

Liquid