MCM2 Antilichaam - N-terminaal gebied: FITC (ARP36647 T100-FITC)

Minichromosome maintenance complex component 2

BM28, CCNL1, CDCL1, cdc19, DFNA70, D3S3194, MITOTIN

4171

P49736

NP_004517

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human MCM2

The protein encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

HUWE1; MCM6; CHFR; SUMO2; MCMBP; UBC; SUMO1; MDM2; MCM7; MCM4; HSP90AB1; ACLY; PRRC1; HYOU1; CAP1; NCL; POLA1; TONSL; SNF8; ELL; TCEA1; POLR2A; CDK6; CDK4; CDC6; MCM10; ORC6; CCNB2; VCAM1; P2RX4; ORC5; ORC2; MCM5; MCM3; ITGA4; FN1; CSNK2A1; CDKN2A; DBF4

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

MCM2 is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

99kDa

Yu, Z., et al., (2004) J. Mol. Biol. 340 (5), 1197-1206

Wet Ice

904

MCM2

MCM2

Rabbit

DNA replication licensing factor MCM2

NM_004526

PGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGM