MCM3AP Antilichaam

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.

8888

O60318

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human MCM3AP (NP_003897.2) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 70kDa

IgG

WB: 1:500 - 1:2000

MCM3AP

HeLa

COS-7

NIH/3T3

Mouse brain

Minichromosome maintenance complex component 3 associated protein

Homo sapiens

GANP, MAP8PNRIID, SAC3, germinal-center associated nuclear protein, 80 kDa MCM3-associated protein, MCM3 acetylating protein, MCM3 acetyltransferase, MCM3 import protein, MCM3 minichromosome maintenance deficient 3 associated protein, germinal center-associated nuclear protein, germinal-centre associated nuclear protein

WB

Liquid