MCM6 Antilichaam - C-terminalgebied: FITC (ARP36650_T100-FITC)

Minichromosome maintenance complex component 6

Mis5, P105MCM, MCG40308

4175

Q14566

NP_005906

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human MCM6

The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

MCM10; HUWE1; SNRPB2; MCM2; NUDT2; ZBTB9; FAM161A; UBC; SUMO2; SUMO3; MCMBP; POLK; MCM4; MCM3; KPNA3; HSP90AB1; CDKN2A; ACLY; CAP1; ING5; MCM6; BAG3; TONSL; MMS22L; ASF1B; SMC1A; MCM7; CCNA1; VCAM1; ITGA4; FN1; gag-pol; GMNN; ORC6; DBF4; CDC7; PAXIP1; TP5

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

90kDa

Yabuta, N., et al., (2003) Genes Cells 8 (5), 413-421

Wet Ice

821

MCM6

MCM6

Rabbit

DNA replication licensing factor MCM6

NM_005915

RIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLE