MCP-1 Antilichaam [1A7B8]

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH) . Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

6347

P13500

P13500

Human

Ni-NTA purified recombinant human MCP-1 expressed in E.Coli strain BL21 (DE3) .

1A7B8

Unconjugated

Primary Antibodies

Innate Immunity

Antibody is purified by protein A affinity chromatography.

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

To MCP-1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1.kappa

CCL2

Chemokine (C-C motif) ligand 2

Homo sapiens

Yoshimura T. et al. 1989. FEBS Lett. 244:487-493.

Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56.

Rollins B.J. et al. 1991. Genomics. 10:489-492.

MCP1, SCYA2, HC11, MCAF, MCP1, MCP-1, GDCF-2, SMC-CF, HSMCR30

ELISA, WB

126842