MCP-2 (CCL8) (Diervrij)

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-2 (CCL8) is an 8.9 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

CCL8; HC14; MCP2; MCP-2; SCYA8; SCYA10

6355

P80075

NP_005614

NM_005623

17q11.2

Human

Hamster, Monkey, Mouse, Rat, Human

QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP

< 0.01 ng/µg of protein (< 0.1 EU/µg)

≥ 98% by SDS-PAGE gel and HPLC analyses.

Determined by its ability to chemoattract monocytic leukemia THP-1 cells.

76

Lyophilized

8.9 kDa

E. coli