MCP-3 (CCL7)

The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant human MCP-3 is a 9.0 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7

6354

P80098

NP_006264

NM_006273

17q11.2-q12

Human

Hasmter, Monkey, Mouse, Human

QPVGINTSTT CCYRFINKKI PKQRLESYRR TTSSHCPREA VIFKTKLDKE ICADPTQKWV QDFMKHLDKK TQTPKL

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract BaF3 cells expressing human CCR2 receptor using a concentration range of 300-500 ng/ml.

76

Lyophilized

9 kDa

E. coli