MCP-4 (CCL13)

The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross- reacts across species. Recombinant murine MCP-2 is an 8.6 kDa protein containing 75 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13

6357

Q99616

NP_005399

NM_005408

17q11.2

Human

Monkey, Mouse, Human, Leech

QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human monocytes using a concentration of 10.0-100.0 ng/ml.

75

Lyophilized

8.6 kDa

E. coli