MCP2 (CCL8) (NM 005623) Humaan Recombinant Proteïne

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8), esidues 24-99aa, with C-terminal DDK tag, expressed in human cells.

HC14; MCP-2; MCP2; SCYA8; SCYA10

6355

P80075

NM_005623

17q12

HEK293

C-DDK

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

>50 ug/mL as determined by microplate BCA method

> 90% as determined by SDS-PAGE and Coomassie blue staining

Liquid

PBS, pH7.4, 10% glycerol

Druggable Genome, Secreted Protein

9.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

CCL8

Human

NP_005614

https://www.ncbi.nlm.nih.gov/gene/6355

https://www.uniprot.org/uniprot/P80075

https://www.ncbi.nlm.nih.gov/nuccore/NM_005623

https://www.ncbi.nlm.nih.gov/nuccore/NP_005614