MD-2 Antilichaam [1A2E3]

MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

23643

Q9Y6Y9

NP_056179

Human, Mouse, Rat

Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2.

1A2E3

Unconjugated

Primary Antibodies

Innate Immunity

MD-2 Monoclonal Antibody is Protein A purified.

Cat. No. 95-108 - MD-2 Recombinant Protein

1 mg/mL

MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MD-2 monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG1

LY96

Cat. No. 10-901 - Human Spleen Tissue Slide

Lymphocyte antigen 96

Homo sapiens

O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.

Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.

Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.

MD-2 Antibody [1A2E3] : MD2, MD-2, ly-96, ESOP-1

ELISA, WB, IHC-P, IF, ICC

223555998

Liquid