MD-2 Antilichaam

MD-2 Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

23643

Q9Y6Y9

NP_056179

Human, Mouse, Rat

3289

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 1) : Anti-MD-2 antibodies (3289) detected human MD-2 recombinant protein at different concentrations. Recombinant Protein Test3289

Innate Immunity

MD-2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1406 - Mouse Spleen Tissue Lysate

1 mg/mL

MD-2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MD-2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human MD-2 has 2 isoforms, including isoform 1 (160aa, 18kD) and isoform 2 (130aa, 15kD) . Mouse MD-2 has one isoform (160aa, 18kD) and Rat MD-2 also has one isoform (160aa, 18kD) . 3289 can detect human, mouse and rat.

LY96

Cat. No. 1466 - Rat Spleen Tissue Lysate

Cat. No. 10-901 - Human Spleen Tissue Slide

Lymphocyte antigen 96

Homo sapiens

O'Neill et al. Trends in Imm. 2003; 24:286-9.

Vogel. Mol. Interv. 2003; 3:466-77.

Takeda et al. Annu. Rev. Immunol. 2003; 21:335-76.

Janeway et al. Annu. Rev. Immunol. 2002; 20:197-216.

MD-2 Antibody: MD2, MD-2, ly-96, ESOP-1, ESOP1, MD2, Lymphocyte antigen 96, Ly-96

ELISA, WB, IHC-P, IF

223555998

Liquid