MDA5 (IFIH1) Mouse Monoclonal Antibody [Kloon ID: LBI11C11]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

Carrier-free (BSA/glycerol-free) IFIH1 mouse monoclonal antibody, clone LBI11C11

AGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2

Homo sapiens interferon induced with helicase C domain 1 (IFIH1), mRNA.

64135

Q9BYX4

Unconjugated

RIG-I-like receptor signaling pathway

RIG-I-like receptor signaling pathway

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

IFIH1

https://www.ncbi.nlm.nih.gov/gene/?term=64135

https://www.uniprot.org/uniprot/Q9BYX4