MDC1 Antilichaam

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

9656

Q14676

Mouse

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MDC1 (NP_055456.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Mouse testis

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 226kDa

IgG

WB: 1:500 - 1:2000

MDC1

Mediator of DNA-damage checkpoint 1

Homo sapiens

IER3, NFBD1, KIAA0170, DKFZp781A0122

WB

Liquid