MDMX (MDM4) Muismonoklonale antilichamen [Kloon ID: LBI2B8]

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Carrier-free (BSA/glycerol-free) MDM4 mouse monoclonal antibody, clone LBI2B8

HDMX; MDMX; MRP1

Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 1, mRNA.

4194

O15151

Unconjugated

P53 signaling pathway

P53 signaling pathway

WB 1:2000, IHC 1:150, IF 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transcription Factors

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

MDM4

https://www.ncbi.nlm.nih.gov/gene/?term=4194

https://www.uniprot.org/uniprot/O15151