MDS1 Antilichaam - N-terminalgebied: FITC (ARP38536_T100-FITC)

Myelodysplasia syndrome 1

PRDM3, MDS1-EVI1

4197

Q13465

NP_004982

Human, Mouse, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human MDS1

MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped. MDS1 has been identified as a single gene as well as a previously unreported exon (s) of EVI1. MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame. In cells with translocation t (3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1. EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

0.5 mg/ml

Human: 100%; Mouse: 93%; Zebrafish: 77%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

19kDa

Fears, S., et al., (1996) Proc. Natl. Acad. Sci. U.S.A. 93 (4), 1642-1647

Wet Ice

169

MDS1

MDS1

Rabbit

MDS1 and EVI1 complex locus protein MDS1

NM_004991

MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPA