ME1 Antilichaam

ME1, also known as NADP-ME, MES or HUMNDME, may play an important role as a housekeeping protein within the cell (1) . ME1 is a 572 amino acid cytoplasmic protein that belongs to the malic enzyme family (2) . It is expressed ubiquitously with highest expression in liver and white adipose tissue. ME1 functions as an NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis (3) . The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles (3,4) . ME1 is regulated by both thyroid hormone levels and the amount of carbohydrates in the diet (5) .

4199

P48163

NP_002386

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

ME1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

ME1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ME1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ME1 antibody is human, mouse and rat reactive. ME1 antibody is predicted not to cross-react with ME2.

ME1

Malic enzyme 1, NADP (+) -dependent, cytosolic

Homo sapiens

Loeber G, Dworkin MB, Infante A, et al. Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 1994; 344:181-6.

Gonzalez-Manchon C, Ferrer M, Ayuso MS, et al. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene 1995;159:255-60.

Gonzalez-Manchon C, Butta N, Ferrer M, et al. Molecular cloning and functional characterization of the human cytosolic malic enzyme promoter: thyroid hormone responsiveness. DNA Cell Biol. 1997;16:533-44.

Yang Z, Lanks CW and Tong L. Molecular mechanism for the regulation of human mitochondrial NAD (P) +-dependent malic enzyme by ATP and fumarate. Structure 2002; 10:951-60.

ME1 Antibody: MES, HUMNDME, NADP-dependent malic enzyme, Malic enzyme 1, NADP-ME

ELISA, WB, IHC-P

4505143

Liquid