ME2 Antilichaam

ME2 is a homotetrameric, mitochondrial NAD-dependent malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate (1) . It is related to malic enzyme 1 (ME1), a cytoplasmic NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis (2) . The expression of both malic enzymes is reciprocally regulated by p53; this regulation has been shown to modulate metabolism and senescence (3) . Certain single-nucleotide polymorphism haplotypes of the ME2 gene have been shown to increase the risk for idiopathic generalized epilepsy (4) .

4200

P23368

NP_002387

Human

Unconjugated

Primary Antibodies

Homeostasis

ME2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

ME2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ME2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ME2 antibody is human specific. At least two isoforms of ME2 are known to exist; this antibody will detect both isoforms. ME2 antibody is predicted not to cross-react with ME1.

ME2

Cat. No. 10-901 - Human Spleen Tissue Slide

Malic enzyme 2, NAD (+) -dependent, mitochondrial

Homo sapiens

Loeber G, Infante AA, Maurer-Fogy I, et al. Human NAD (+) -dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. J. Biol. Chem. 1991; 266:3016-21.

Gonzalez-Manchon C, Ferrer M, Ayuso MS, et al. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene 1995;159:255-60.

Jiang P, Du W, Mancuso A, et al. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 2013; 493:689-83.

Lenzen KP, Heils A, Lorenz S, et al. Association analysis of malic acid enzyme 2 gene polymorphisms with idiopathic generalized epilepsy. Epilepsia 2005; 46:1637-41.

ME2 Antibody: ODS1, NAD-dependent malic enzyme, mitochondrial, Malic enzyme 2, NAD-ME

ELISA, WB, IHC-P, IF

4505145

Liquid