MEC (CCL28)

MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary glad, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

CCL28; MEC; CCK1; SCYA28

56477

Q9NRJ3

NP_683513.1

NM_148672

5p12

Human

Human, Bacteria

SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-10.0 ng/ml.

108

Lyophilized

12.3 kDa

E. coli