MECR Antilichaam

MECR Antibody: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.

51102

Q9BV79

NP_057095

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

MECR Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

MECR Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MECR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 41 kDa

IgG

At least two isoforms of MECR are known to exist; this antibody will detect both isoforms.

MECR

Cat. No. 1403 - Mouse Brain Tissue Lysate

Cat. No. 1463 - Rat Brain Tissue Lysate

Mitochondrial trans-2-enoyl-CoA reductase

Homo sapiens

Masuda N, Yasumo H, Furusawa T, et al. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene 1998; 221:225-33.

Chen Z, Leskinen H, Liimatta E, et al. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One 2009; 4:e5589.

MECR Antibody: NRBF1, CGI-63, FASN2B, NBRF1, Trans-2-enoyl-CoA reductase, mitochondrial, Nuclear receptor-binding factor 1, HsNrbf-1

ELISA, WB

67078404

Liquid