MED23 Antilichaam

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

9439

Q9ULK4

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 890-1110 of human MED23 (NP_001257450.1) .

Unconjugated

Primary Antibodies

Signal Transduction

Affinity purification

Mouse brain

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 170kDa

IgG

WB: 1:500 - 1:2000

MED23

Rat brain

Mediator complex subunit 23

Homo sapiens

ARC13CRSP13CRSP133, CRSP3, DRIP13MRT18, SUR-2, SUR2, mediator of RNA polymerase II transcription subunit 23, 130 kDa transcriptional co-activator, 133 kDa transcriptional co-activator, activator-recruited cofactor 130 kDa component, cofactor required for Sp1 transcriptional activation subunit 3, vitamin D3 receptor interacting protein

WB

Liquid