MED4 Antilichaam

MED4 Antibody: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED4. This protein has also been shown to be part of the vitamin D receptor interacting complex. MED4 was recently identified as an HIV dependency factor (HDF), suggesting that MED4 may be an important drug target in HIV treatment.

29079

Q9NPJ6

NP_054885

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Infectious Disease

MED4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (86%)

MED4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MED4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of MED4 are known to exist; this antibody only recognizes the largest isoform.

MED4

Cat. No. 11-701 - Human Testis Tissue Slide

Mediator complex subunit 4

Homo sapiens

Sato S, Tomomori-Sato C, Parmely TJ, et al. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol. Cell2004; 14:685-91.

Gustafsson CM, Myers LC, Beve J, et al. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J. Biol. Chem.1998; 273:30851-4.

Rachez C, Lemon BD, Suldan Z, et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature1999; 398:824-8.

Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.

MED4 Antibody: ARC36, VDRIP, DRIP36, TRAP36, HSPC126, ARC36, Mediator of RNA polymerase II transcription subunit 4, Activator-recruited cofactor 36 kDa component

ELISA, WB, IHC-P

7661788

Liquid