Mefenytoin-d3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
(Rac) -Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].
1185101-86-3
12352005
Cytochrome P450; Isotope-Labeled Compounds
Metabolic Enzyme/Protease; Others
Neuroscience-Neuromodulation
Neurological Disease
10 mM in DMSO
C(C)C1(C(=O)N(C([2H])([2H])[2H])C(=O)N1)C2=CC=CC=C2
C12H11D3N2O2
221.27
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64 (4) :387-398.|[3]Relling MV, et al. Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections. Pharmacogenetics. 1991;1 (1) :42-49.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-B1184S/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
(Rac) -Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].
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