MEGF10 Polyklonale Antilichaam, APC-vervoeging

MEGF10 is a 1,140 amino acid protein encoded by the human gene MEGF10. MEGF10 belongs to the MEGF family and contains fifteen EGF-like domains and one EMI domain. The engulfment of dying cells is a specialized form of phagocytosis that is highly conserved across evolution and is mediated by the concerted action of several molecules. MEGF10 is an engulfment receptor protein that localizes to the plasma membrane in a punctuated pattern. The MEGF10 protein shares structural similarities with nematode engulfment receptor cell death abnormal-1 (CED-1) . MEGF10 function is modulated by the ATP binding cassette transporter ABCA1, which is an ortholog to CED-7. It is expressed at the cell surface in clusters around cell corpses during engulfment, and during the engulfment of apoptotic thymocytes is recruited to the bottom of the forming phagocytic cup.

MEG10_HUMAN; MEGF protein; megf10; Multiple EGF-like domains protein 10; multiple EGF-like-domains 10; Multiple epidermal growth factor-like domains 10; Multiple epidermal growth factor-like domains protein 10.

84466

Cell membrane

55-150/1140

MEGF10

APC

KLH conjugated synthetic peptide derived from human MEGF10

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

650nm/660nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

84466

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken